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Proteomics Approaches for the Early Detection of Pollution-Related Human Diseases: A Review
Authors
1 College of Biotechnology, U.P. Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan, Sansthan (DUVASU), Mathura, India. Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, Uttar Pradesh, India. 2 Kishan Lal Public College, Rewari, Haryana, India. . 1 3 4 Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, Uttar Pradesh, India.
Article Information
- DOI
- No DOI
- Published In
- Volume 6, Issue 6 (2026)
- Published Online
- November-December 2026
- Pages
- 32-34
- Article Type
- Review Article
- Check for updates
- No DOI available for cross-reference
References
1. Wei, C., Zeng, B., Zhou, X., Qing, B., Deng, L., Wu, Y., Huang, W., Zhang, Z., Jin, Y., Peng, S., Zhang, C., & Qiu, S. (2026). Proteomics in environmental pollution research: Advances, challenges, and future directions. Journal of Proteomics, 331, 105693. https://doi.org/10.1016/j.jprot.2026.105693
2. Li, W., Li, K., Zhou, P., Cheng, Y., Zhao, Y., Meng, X., Niu, Y., Zong, G., Zhang, G., Kan, H., & Wang, S. (2026). Plasma proteome mediates the associations between air pollution exposure and disease risk. Nature Communications, 17, Article 2206. https://doi.org/10.1038/s41467-026-68972-6
3. Wild, C. P. (2005). Complementing the genome with an “exposome”: The outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiology, Biomarkers & Prevention, 14(8), 1847–1850. https://doi.org/10.1158/1055-9965.EPI-05-0456
4. Sheehan, D. (2007). The potential of proteomics for providing new insights into environmental impacts on human health. Reviews on Environmental Health, 22(3), 175–194. https://doi.org/10.1515/reveh.2007.22.3.175
5. Geyer, P. E., Holdt, L. M., Teupser, D., & Mann, M. (2017). Revisiting biomarker discovery by plasma proteomics. Molecular Systems Biology, 13(9), 942. https://doi.org/10.15252/msb.20156297
6. Dennis, K. K., et al. (2017). Biomonitoring in the era of the exposome. Environmental Health Perspectives, 125(4), 502–510. https://doi.org/10.1289/EHP474
7. Wallace, M. A. G., Kormos, T. M., & Pleil, J. D. (2016). Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science. Journal of Toxicology and Environmental Health, Part B, 19(8), 380–409. https://doi.org/10.1080/10937404.2016.1215772
8. Nadeau, K., et al. (2025). Exposomics: A review of methodologies, applications, and future directions in molecular medicine. [Verify the final journal citation and author list before submission.] https://pmc.ncbi.nlm.nih.gov/articles/PMC11982546/
9. Biomarkers of the health outcomes associated with ambient particulate matter exposure. (2017). Science of the Total Environment, 579, 1446–1459. https://doi.org/10.1016/j.scitotenv.2016.11.146.
2. Li, W., Li, K., Zhou, P., Cheng, Y., Zhao, Y., Meng, X., Niu, Y., Zong, G., Zhang, G., Kan, H., & Wang, S. (2026). Plasma proteome mediates the associations between air pollution exposure and disease risk. Nature Communications, 17, Article 2206. https://doi.org/10.1038/s41467-026-68972-6
3. Wild, C. P. (2005). Complementing the genome with an “exposome”: The outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiology, Biomarkers & Prevention, 14(8), 1847–1850. https://doi.org/10.1158/1055-9965.EPI-05-0456
4. Sheehan, D. (2007). The potential of proteomics for providing new insights into environmental impacts on human health. Reviews on Environmental Health, 22(3), 175–194. https://doi.org/10.1515/reveh.2007.22.3.175
5. Geyer, P. E., Holdt, L. M., Teupser, D., & Mann, M. (2017). Revisiting biomarker discovery by plasma proteomics. Molecular Systems Biology, 13(9), 942. https://doi.org/10.15252/msb.20156297
6. Dennis, K. K., et al. (2017). Biomonitoring in the era of the exposome. Environmental Health Perspectives, 125(4), 502–510. https://doi.org/10.1289/EHP474
7. Wallace, M. A. G., Kormos, T. M., & Pleil, J. D. (2016). Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science. Journal of Toxicology and Environmental Health, Part B, 19(8), 380–409. https://doi.org/10.1080/10937404.2016.1215772
8. Nadeau, K., et al. (2025). Exposomics: A review of methodologies, applications, and future directions in molecular medicine. [Verify the final journal citation and author list before submission.] https://pmc.ncbi.nlm.nih.gov/articles/PMC11982546/
9. Biomarkers of the health outcomes associated with ambient particulate matter exposure. (2017). Science of the Total Environment, 579, 1446–1459. https://doi.org/10.1016/j.scitotenv.2016.11.146.
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