ARCHIVES
Year 2026 · Volume 6 · Issue 5
Review Article
Onosma Bracteatum Wall (Gojihva): A Promising Anti-Arthritic Herb
V. Sri Sowmya1
Dr.V.Bhaskara Raju2
K. Lakshmi Durga3
K.Pravallika4
V. Suvarna Rani5
T.Lakshmi Priya6
K. Pavani7
1 Assistant Professor,Sri Vasavi Institute of Pharmaceutical Sciences, Pedatadepalli, Tadepalligudem, Andhra Pradesh, India. 2 Principal and Professor, Sri Vasavi Institute of Pharmaceutical Sciences,Pedatadepalli,Tadepalligudem, AndhraPradesh, India. 3 4 5 6 7 Student, Sri Vasavi Institute of Pharmaceutical Sciences, Pedatadepalli, Tadepalligudem, Andhra Pradesh, India.
Published Online: September-October 2026
Pages: 459-466
Cite this article
↗ https://www.doi.org/10.59256/ijrtmr.20260605050
References
1. F. Radu, S. G. Bungau, et al., —Management of rheumatoid arthritis: An overview,‖ Cells, vol. 10, no. 11, p. 2857, 2021, doi: 10.3390/cells10112857.
2. W. Grassi, R. De Angelis, G. Lamanna, et al., —The clinical features of rheumatoid arthritis,‖ European Journal of Radiology, vol. 27, Suppl. 1, 1998, doi: 10.1016/S0720-048X(98)00038-2.
3. T.Koike,—Treatmentofrheumatoidarthritisbymolecular-
a targetedagents:Efficacyandlimitations,‖JournalofOrthopaedicScience,vol.20,no.6,pp.951–957,2015,doi: 10.1007/s00776-015-0766-9.
4. P.Conigliaro,P.Triggianese,E.DeMartino,etal.,—Challengesinthetreatmentofrheumatoidarthritis,‖AutoimmunityReviews,vol.18,no.7,pp.706–713,2019,doi: 10.1016/j.autrev.2019.05.007.
5. F. Zafar, H. M. Asif, M. Farhan, et al., —Onosma bracteatum Wall. aqueous-ethanolic extract suppresses complete Freund's adjuvant-induced arthritis in rats via regulation of TNF-α, IL-6, and C-reactive protein,‖ Molecules, vol. 29, no. 8, p. 1830, 2024, doi: 10.3390/molecules29081830.
6. U.VegadandD.J.Pandya,—EvaluationofdiureticandlaxativepotentialofOnosmabracteataWall.:Aspeciesofthecontroversialdrug
a.‗Gojihva‘,‖IndianJournalofPharmaceuticalInnovation,vol.3,p.60,2022,doi:10.5530/ijpi.2022.3.60.
7. N.Kumar,R.Kumar,K.Kishore,etal.,—OnosmaL.:Areviewofphytochemistryandethnopharmacology,‖ PharmacognosyReviews,vol.7,no. 14,pp.140–145,2013,doi:10.4103/0973-7847.120513.
8. J. Jabbar,F.O. Abdullah, A. O. Hassan, etal.,—Ethnobotanical, phytochemistry, and pharmacological activityofOnosma (Boraginaceae): An updated review,‖ Molecules, vol. 27, no. 24, p. 8687, 2022, doi: 10.3390/molecules27248687.
9. U. G. Vegad and D. J. Pandya, —A comprehensive review on Onosma bracteata Wall.: A controversial medicinal herb in Ayurveda,‖ 2023, doi: 10.2174/2215083808666220816105019.
10. S.Sahu,D.U.Nayak,P.K.Panda,etal.,—TherapeuticpotentialofOnosmabracteatumWall.,sourceofplantGojihva,‖2024,doi: 10.7897/2277-4343.16127.
11. H. M. Asif, A. Hayee, M. R. Aslam, et al., —RETRACTED: Dose-dependent, antidepressant, and anxiolytic effects of a traditional medicinalplant for the management of behavioral dysfunctions in animal models,‖ 2019, doi: 10.1177/1559325819891262.
12. N.HovelmeyerandC.Ohnmacht,—NF-κBincontrolofregulatoryTcelldevelopment,identityandfunctions,‖2022.
13. I.Leversen,A.G.Danielsen,M.S.Birkeland,etal.,—Basicpsychologicalneedsatisfactioninleisureactivitiesandadolescents'life satisfaction,‖ Journal of Youth and Adolescence, vol. 41, no. 12, pp. 1588–1599, 2012, doi: 10.1007/s10964-012-9776-5.
14. L. Cao, Y.Xue, Z. Yang, etal., —Shikonofuran E plays an anti-inflammatoryrole bydown-regulatingMAPK and NF-κB signalingpathways in lipopolysaccharide-stimulated RAW264.7 macrophages,‖ Journalof Natural Medicines, vol. 73, no. 1, pp. 244–251, 2019, doi: 10.1007/s11418-018-1238-2.
15. S. Tanaka, T. Toki, M. Yokoyama, et al., —Anovel inhibitor ofI-kappaB kinasebeta amelioratesexperimental arthritis throughdownregulation of proinflammatory cytokines in arthritic joints,‖ Biological & Pharmaceutical Bulletin, vol. 37, 2014, doi: 10.1248/bpb.b13-00628.
16. P.Soni,S.V.Kamble,etal.,—Extraction,antioxidantactivityandHPLCstudy of bioactivecompoundpresentinleavesextractofOnosma bracteatum,‖ Journal of Natural Sciences, vol. 14, p. 2697, 2025, doi: 10.52783/jns.v14.2697.
17. L.A.Pham-Huy,H.He,andC.Pham-Huy,—Freeradicals,antioxidantsindiseaseandhealth,‖ InternationalJournalofBiomedicalScience,vol. 4, no. 2, pp. 89–96, 2008.
18. M.F.Mahomoodally,N.Sadeer,M.Edoo,etal.,—Thepotentialapplicationofnoveldrugdeliverysystemsforphytopharmaceuticalsand natural extracts—current status and future perspectives.‖
19. Z.Usmani,Z.Usmani,A.Ahmad,etal.,—Phytochemical-basednanotherapeuticsforskincancer:Acriticalappraisalofcurrentstrategies, challenges, and future perspectives,‖ Chemistry & Biodiversity, 2026, doi: 10.1002/cbdv.202502609.
20. K.Sakure,A.Patel,M.Pradhan,etal.,—Recenttrendsandfutureprospectsofphytosomes:Aconcisereview,‖JournalofPharmaceutical Sciences, 2024, doi: 10.36468/pharmaceutical-sciences.1334.
21. P. G. Swami, D. J. Singhavi, R. O. Ganjiwale,et al., —An examination of research trends in phytosome technology for phytoactive delivery:Progress and future directions,‖ 2026, doi: 10.52711/0974-360X.2026.00132.
22. S.Jacob,F.S.Kather,S.H.S.Boddu,etal.,—Vesicularcarriersforphytochemicaldelivery:Acomprehensivereviewoftechniquesand applications,‖ Pharmaceutics, vol. 17, no. 4, p. 464, 2025, doi: 10.3390/pharmaceutics17040464.
23. I.Rahat,P.Yadav,A.Singhal,etal.,—Polymerlipidhybridnanoparticlesforphytochemicaldelivery:Challenges,progress,andfuture prospects,‖ Beilstein Journal of Nanotechnology, vol. 15, p. 118, 2024, doi: 10.3762/bjnano.15.118.
24. A.Zielińska,F.Carreiro,A.M.Oliveira,etal.,—Polymericnanoparticles:Production,characterization,toxicologyandecotoxicology,‖Molecules, vol. 25, no. 16, p. 3731, 2020, doi: 10.3390/molecules25163731.
25. N. Lal,V. Rastogi,R. Mishra, etal., —Polymeric nanoparticles:A promising pharmaceuticalapproachfor advanceddrug delivery systems,‖ 2026, doi: 10.2174/0122117385360894251031063012.
26. U. Farooq, Y. Pan, D. Disasa, et al., —Novel anti-aging benzoquinone derivatives from Onosma bracteatum Wall.,‖ Molecules, vol. 24, no. 7, p. 1428, 2019, doi: 10.3390/molecules24071428.
2. W. Grassi, R. De Angelis, G. Lamanna, et al., —The clinical features of rheumatoid arthritis,‖ European Journal of Radiology, vol. 27, Suppl. 1, 1998, doi: 10.1016/S0720-048X(98)00038-2.
3. T.Koike,—Treatmentofrheumatoidarthritisbymolecular-
a targetedagents:Efficacyandlimitations,‖JournalofOrthopaedicScience,vol.20,no.6,pp.951–957,2015,doi: 10.1007/s00776-015-0766-9.
4. P.Conigliaro,P.Triggianese,E.DeMartino,etal.,—Challengesinthetreatmentofrheumatoidarthritis,‖AutoimmunityReviews,vol.18,no.7,pp.706–713,2019,doi: 10.1016/j.autrev.2019.05.007.
5. F. Zafar, H. M. Asif, M. Farhan, et al., —Onosma bracteatum Wall. aqueous-ethanolic extract suppresses complete Freund's adjuvant-induced arthritis in rats via regulation of TNF-α, IL-6, and C-reactive protein,‖ Molecules, vol. 29, no. 8, p. 1830, 2024, doi: 10.3390/molecules29081830.
6. U.VegadandD.J.Pandya,—EvaluationofdiureticandlaxativepotentialofOnosmabracteataWall.:Aspeciesofthecontroversialdrug
a.‗Gojihva‘,‖IndianJournalofPharmaceuticalInnovation,vol.3,p.60,2022,doi:10.5530/ijpi.2022.3.60.
7. N.Kumar,R.Kumar,K.Kishore,etal.,—OnosmaL.:Areviewofphytochemistryandethnopharmacology,‖ PharmacognosyReviews,vol.7,no. 14,pp.140–145,2013,doi:10.4103/0973-7847.120513.
8. J. Jabbar,F.O. Abdullah, A. O. Hassan, etal.,—Ethnobotanical, phytochemistry, and pharmacological activityofOnosma (Boraginaceae): An updated review,‖ Molecules, vol. 27, no. 24, p. 8687, 2022, doi: 10.3390/molecules27248687.
9. U. G. Vegad and D. J. Pandya, —A comprehensive review on Onosma bracteata Wall.: A controversial medicinal herb in Ayurveda,‖ 2023, doi: 10.2174/2215083808666220816105019.
10. S.Sahu,D.U.Nayak,P.K.Panda,etal.,—TherapeuticpotentialofOnosmabracteatumWall.,sourceofplantGojihva,‖2024,doi: 10.7897/2277-4343.16127.
11. H. M. Asif, A. Hayee, M. R. Aslam, et al., —RETRACTED: Dose-dependent, antidepressant, and anxiolytic effects of a traditional medicinalplant for the management of behavioral dysfunctions in animal models,‖ 2019, doi: 10.1177/1559325819891262.
12. N.HovelmeyerandC.Ohnmacht,—NF-κBincontrolofregulatoryTcelldevelopment,identityandfunctions,‖2022.
13. I.Leversen,A.G.Danielsen,M.S.Birkeland,etal.,—Basicpsychologicalneedsatisfactioninleisureactivitiesandadolescents'life satisfaction,‖ Journal of Youth and Adolescence, vol. 41, no. 12, pp. 1588–1599, 2012, doi: 10.1007/s10964-012-9776-5.
14. L. Cao, Y.Xue, Z. Yang, etal., —Shikonofuran E plays an anti-inflammatoryrole bydown-regulatingMAPK and NF-κB signalingpathways in lipopolysaccharide-stimulated RAW264.7 macrophages,‖ Journalof Natural Medicines, vol. 73, no. 1, pp. 244–251, 2019, doi: 10.1007/s11418-018-1238-2.
15. S. Tanaka, T. Toki, M. Yokoyama, et al., —Anovel inhibitor ofI-kappaB kinasebeta amelioratesexperimental arthritis throughdownregulation of proinflammatory cytokines in arthritic joints,‖ Biological & Pharmaceutical Bulletin, vol. 37, 2014, doi: 10.1248/bpb.b13-00628.
16. P.Soni,S.V.Kamble,etal.,—Extraction,antioxidantactivityandHPLCstudy of bioactivecompoundpresentinleavesextractofOnosma bracteatum,‖ Journal of Natural Sciences, vol. 14, p. 2697, 2025, doi: 10.52783/jns.v14.2697.
17. L.A.Pham-Huy,H.He,andC.Pham-Huy,—Freeradicals,antioxidantsindiseaseandhealth,‖ InternationalJournalofBiomedicalScience,vol. 4, no. 2, pp. 89–96, 2008.
18. M.F.Mahomoodally,N.Sadeer,M.Edoo,etal.,—Thepotentialapplicationofnoveldrugdeliverysystemsforphytopharmaceuticalsand natural extracts—current status and future perspectives.‖
19. Z.Usmani,Z.Usmani,A.Ahmad,etal.,—Phytochemical-basednanotherapeuticsforskincancer:Acriticalappraisalofcurrentstrategies, challenges, and future perspectives,‖ Chemistry & Biodiversity, 2026, doi: 10.1002/cbdv.202502609.
20. K.Sakure,A.Patel,M.Pradhan,etal.,—Recenttrendsandfutureprospectsofphytosomes:Aconcisereview,‖JournalofPharmaceutical Sciences, 2024, doi: 10.36468/pharmaceutical-sciences.1334.
21. P. G. Swami, D. J. Singhavi, R. O. Ganjiwale,et al., —An examination of research trends in phytosome technology for phytoactive delivery:Progress and future directions,‖ 2026, doi: 10.52711/0974-360X.2026.00132.
22. S.Jacob,F.S.Kather,S.H.S.Boddu,etal.,—Vesicularcarriersforphytochemicaldelivery:Acomprehensivereviewoftechniquesand applications,‖ Pharmaceutics, vol. 17, no. 4, p. 464, 2025, doi: 10.3390/pharmaceutics17040464.
23. I.Rahat,P.Yadav,A.Singhal,etal.,—Polymerlipidhybridnanoparticlesforphytochemicaldelivery:Challenges,progress,andfuture prospects,‖ Beilstein Journal of Nanotechnology, vol. 15, p. 118, 2024, doi: 10.3762/bjnano.15.118.
24. A.Zielińska,F.Carreiro,A.M.Oliveira,etal.,—Polymericnanoparticles:Production,characterization,toxicologyandecotoxicology,‖Molecules, vol. 25, no. 16, p. 3731, 2020, doi: 10.3390/molecules25163731.
25. N. Lal,V. Rastogi,R. Mishra, etal., —Polymeric nanoparticles:A promising pharmaceuticalapproachfor advanceddrug delivery systems,‖ 2026, doi: 10.2174/0122117385360894251031063012.
26. U. Farooq, Y. Pan, D. Disasa, et al., —Novel anti-aging benzoquinone derivatives from Onosma bracteatum Wall.,‖ Molecules, vol. 24, no. 7, p. 1428, 2019, doi: 10.3390/molecules24071428.
Related Articles
2026
A Strategic Framework for Depth-Dependent Hydroelectric Conversion along the Indian Coastline
2026
Reimagining Development in India: A Critical Analysis of the Viksit Bharat Vision
2026
AI-Enabled Image Description: Bridging the Gap for the Visually Impaired
2026
Perceived Occupational Risks of Emergency Medical Services Personnel
2026
Origin, Growth and recent Development of Integrated Reporting (IR): A theoretical Review
2026