Effect of Shirish (Albizia lebbeck Benth.) on Irritant Contact Dermatitis: A Pharmaco-Ayurvedic Appraisal

1. Novak-Bilic G, Vucic M, Japundzic I, Mestrovic-Stefekov J, Stanic-Duktaj S, Lugovic-Mihic L. Irritant and allergic contact dermatitis –
skin lesion characteristics. Acta Clin Croat. 2018;57(4):713-720.
2. Bhatia R, Sharma VK. Occupational dermatoses: An Asian perspective. Indian J Dermatol Venereol Leprol. 2017.
3. Sarma N. Occupational allergic contact dermatitis among construction workers in India. Indian J Dermatol. 2009. doi:10.4103/0019-
5154.53192.
4. Diepgen TL. Occupational skin diseases. J Dtsch Dermatol Ges. 2012;10:297-315.
5. Stacey SK, McEleney M. Topical corticosteroids: choice and application. Am Fam Physician. 2021;103(6):337-343.
6. Niculet E, Bobeica C, Tatu AL. Glucocorticoid-induced skin atrophy: the old and the new. Clin Cosmet Investig Dermatol. 2020;13:1041-
1050.
7. Tripathi B, editor. Charak Samhita, Chikitsasthana, 23rd chapter. Vol 2. Varanasi: Chaukhambha Surabharati; Reprint 2009.
8. Mathur DS. Brihad Nighantu Ratnakar (Part 6), Visharog Chikitsa Adhyaya. Bombay: Khemraj Shrikrushnadas Prakashan; p. 541.
9. Sharma PS. Rasatarangini. 11th ed. Kashinathashastri P, editor. Varanasi: Motilal Banarasidas; 1979. Taranga 21/173-174.
10. Lakkakula BS, Lambat RD. Role of Panchashirisha Agada in dermatological toxicity w.s.r. to Visha - a review. J Ayurveda Integr Med
Sci. 2021;6(1).
11. Manyala SSK, Chalakh SP. Study of Panchashirishadi Agad on the basis of physicochemical and phytochemical analysis. J Indian Syst
Med. 2020;8(2).
12. Mahapatra T, Inchulkar SR, Bhagat S. Role of Pancha Shirisha Agad in the management of Dadru Kushtha: a review. Int Ayurvedic Med
J. 2020.
13. Katiyar S, Gangasagre N. In vitro comparative study of anti-microbial and anti-oxidant activity of Panchshirishagad and Shleshmatakadya
Agada. Osmanabad: Government Ayurved College; 2016-17.
14. Rajebhosale S, Panhale P. Evaluation of the clinical effect of Shirishadi Churna and Karanj Taila in Garbhini Kikkisa (striae gravidarum).
Kolhapur: L.K.R. Ayurvedic Medical College, Gadhinglaj; 2016-17.
15. Akash MM, Pawade U. Detoxifying effect of Shirish, Haridra and Nirgundi from Vishaghna Mahakashaya on pesticidal residue in Shimla
mirch. Nagpur: Shri Ayurved Mahavidyalaya; 2016-17.
16. Balkrishna A, Sakshi, Chauhan M, Dabas A, Arya V. A comprehensive insight into the phytochemical, pharmacological potential, and
traditional medicinal uses of Albizia lebbeck (L.) Benth. Evid Based Complement Alternat Med. 2022;2022:5359669.
17. Mishra SS, Gothecha VK, Sharma A. Albizia lebbeck: a short review. J Herb Med Toxicol. 2010;4(2):9-15.
18. Verma SC, Vashishth E, Singh R, Kumari A, Meena AK, Pant P, Bhuyan GC, Padhi MM. A review on parts of Albizia lebbeck (L.) Benth.
used as Ayurvedic drugs. Res J Pharm Technol. 2013;6(11).
19. Venkatesh P, Mukherjee PK, Kumar NS, Bandyopadhyay A, Fukui H, Mizuguchi H, Islam N. Anti-allergic activity of standardized extract
of Albizia lebbeck with reference to catechin as a phytomarker. Immunopharmacol Immunotoxicol. 2010;32(2):272-276.
20. Prakash Babu N, Pandikumar P, Ignacimuthu S. Anti-inflammatory activity of Albizia lebbeck Benth., an ethnomedicinal plant, in acute
and chronic animal models of inflammation. J Ethnopharmacol. 2009;125(3):356-360.
21. Saha A, Ahmed M. The analgesic and anti-inflammatory activities of the extract of Albizia lebbeck in animal model. Pak J Pharm Sci.
2009;22(1):74-77.
22. Nurul IM, Mizuguchi H, Shahriar M, Venkatesh P, Maeyama K, Mukherjee PK, Hattori M, Choudhuri MSK, Takeda N, Fukui H. Albizia
lebbeck suppresses histamine signaling by the inhibition of histamine H1 receptor and histidine decarboxylase gene transcript ions. Int
Immunopharmacol. 2011;11(11):1766-1772.
23. Zhang EY, Chen AY, Zhu BT. Mechanism of dinitrochlorobenzene-induced dermatitis in mice: role of specific antibodies in pathogenesis.
PLoS One. 2009;4(11):e7703.
24. Organisation for Economic Co-operation and Development. Test No. 404: Acute Dermal Irritation/Corrosion. OECD Guidelines for the
Testing of Chemicals. Paris: OECD Publishing; Adopted 28 July 2015.
25. Patil MB, Chaudhary A. Topical dosage forms (Lepa Kalpana) of Ayurveda: an unexplored treasure. Int J Green Pharm. 2015;9(4
Suppl):S12-S22.
26. Sharangadhara. Sharangadhara Samhita, Madhyama Khanda 6/1. Tripathi B, editor. Varanasi: Chaukhamba Surbharati Prakashan; 2024.
p. 116.
27. Kim SR, Choi HS, Seo HS, Choi YK, Shin YC, Ko SG. Topical application of herbal mixture extract inhibits ovalbumin- or 2,4-
dinitrochlorobenzene-induced atopic dermatitis. Evid Based Complement Alternat Med. 2012;2012:545497.
28. [28] Krishnamurthy MS. Malahara Kalpana: Ayurvedic Ointment Preparation [Internet]. EasyAyurveda; 2016 [cited 2026 Aug 16].
Available from: https://www.easyayurveda.com/2016/04/20/malahara-kalpana-ointment/
29. Arya RP. A critical review on Gandhakadya Malahara. Kerala J Ayurveda. 2022;1(1):49-53.
30. Chunekar KC, Pandey GS, editors. Bhavaprakash Nighantu, Vatadi Varga. Varanasi: Chaukhambha Bharati Academy; Reprint 2010.
31. Sharma PV. Dravyaguna Vigyan, Part 2. Varanasi: Chaukhambha Sanskrit Pratishthan; Reprint 2015.