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A Polyphenol-Rich Ginger, Licorice and Pomegranate Blend Strengthens Gastrointestinal Antioxidant Defenses While Preserving Gastric Acid Homeostasis
Authors
1 Managing Partner, Ambitn; M.Sc. Chemistry, Bharathidasan University, Tamilnadu, India. 2 Assistant Manager, QA/R&D, Ambitn; M.Sc. Food Safety and Quality Management, Indira Gandhi National Open University, New Delhi, India. 3 Senior Research Associate, Ambitn; M.Sc. Chemistry, Mahatma Gandhi University, Kerala, India. 4 Senior Research Associate, Ambitn; M.Sc. Biochemistry, Bharathidasan University, Tamilnadu, India. 5 Senior Consultant, Projects and Operations, Xplora Clinical Research Services Pvt. Ltd., Bangalore, India. 6 Research Scholar, Chitkara University, Rajpura, Punjab, India.
Article Information
- Published In
- Volume 6, Issue 6 (2026)
- Published Online
- November-December 2026
- Pages
- 01-07
- Article Type
- Original Article
- Check for updates
-
References
1. Lanas A, Chan FKL. Peptic ulcer disease. Lancet 2017;390:613-24.
2. Scarpignato C, Gatta L, Zullo A, Blandizzi C. Effective and safe proton pump inhibitor therapy in acid-related diseases. BMC Med 2016;14:179.
3. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe). Food Chem Toxicol 2008;46:409-20.
4. Hu ML, Rayner CK, Wu KL, Chuah SK, Tai WC, Chou YP, et al. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol 2011;17:105-10.
5. Wang Z, Hasegawa J, Wang X, Matsuda A, Tokuda T, Miura N, et al. Protective effects of ginger against aspirin-induced gastric ulcers in rats. Yonago Acta Med 2011;54:11-19.
6. Aregawi LG, Gebremeskel TG, Zoltan C. Preventive and therapeutic effects of ginger on bowel disease: a review of clinical trials. Pharmacol Res Mod Chin Med 2024;12:100457.
7. Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza species and its bioactive compounds. Phytother Res 2008;22:709-24.
8. Panji M, Ghafouri M. Gastroprotective activity of licorice and turmeric rhizome aqueous extract against ethanol-induced gastric injury in male Wistar rats. Med Lab J 2022;16:32-38.
9. Rahnama M, Mehrabani D, Japoni S, Edjtehadi M, Saberi Firoozi M. The healing effect of licorice on Helicobacter pylori-infected peptic ulcers. J Res Med Sci 2013;18:532-33.
10. Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 2006;54:980-85.
11. Colombo E, Sangiovanni E, Dell'Agli M. A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract. Evid Based Complement Alternat Med 2013;2013:247145.
12. [Devi MR, Subramanian NS, Gupta VRM, Prasad BG, Reddy CM. Anti-gastric ulcer activity of Plectranthus amboinicus in Wistar albino rats. J Chem Pharm Res 2010;2:374-80.
13. El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM. Gastroprotective effect of garlic in indomethacin-induced gastric ulcer in rats. Nutrition 2016;32:849-54.
14. Corne SJ. A method for the quantitative estimation of gastric barrier mucus. J Physiol 1974;242:116P-117P.
15. Devasagayam TP, Tarachand U. Decreased lipid peroxidation in the rat kidney during gestation. Biochem Biophys Res Commun 1987;145:134-38.
16. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 1984;21:130-32.
17. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972;47:389-94.
18. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-69.
19. Miwa S. Hematology. Mod Med Technol 1972;3:306-10.
20. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979;582:67-78.
21. Anson ML. The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin. J Gen Physiol 1938;22:79-89.
22. Sipos T, Merkel JR. Effect of calcium ions on the activity, heat stability and structure of trypsin. Biochemistry 1970;9:2766-75.
23. Hummel BC. A modified spectrophotometric determination of chymotrypsin, trypsin and thrombin. Can J Biochem Physiol 1959;37:1393-99.
24. Gamklou R, Schersten T. Activity of alpha-amylase and alpha-1,4-glucosidase in human liver tissue. Scand J Clin Lab Invest 1972;30:201-07.
25. Bergo M, Olivecrona G, Olivecrona T. Forms of lipoprotein lipase in rat tissues. Biochem J 1996;313:893-98.
26. Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 2020;18:e3000410.
2. Scarpignato C, Gatta L, Zullo A, Blandizzi C. Effective and safe proton pump inhibitor therapy in acid-related diseases. BMC Med 2016;14:179.
3. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe). Food Chem Toxicol 2008;46:409-20.
4. Hu ML, Rayner CK, Wu KL, Chuah SK, Tai WC, Chou YP, et al. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol 2011;17:105-10.
5. Wang Z, Hasegawa J, Wang X, Matsuda A, Tokuda T, Miura N, et al. Protective effects of ginger against aspirin-induced gastric ulcers in rats. Yonago Acta Med 2011;54:11-19.
6. Aregawi LG, Gebremeskel TG, Zoltan C. Preventive and therapeutic effects of ginger on bowel disease: a review of clinical trials. Pharmacol Res Mod Chin Med 2024;12:100457.
7. Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza species and its bioactive compounds. Phytother Res 2008;22:709-24.
8. Panji M, Ghafouri M. Gastroprotective activity of licorice and turmeric rhizome aqueous extract against ethanol-induced gastric injury in male Wistar rats. Med Lab J 2022;16:32-38.
9. Rahnama M, Mehrabani D, Japoni S, Edjtehadi M, Saberi Firoozi M. The healing effect of licorice on Helicobacter pylori-infected peptic ulcers. J Res Med Sci 2013;18:532-33.
10. Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 2006;54:980-85.
11. Colombo E, Sangiovanni E, Dell'Agli M. A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract. Evid Based Complement Alternat Med 2013;2013:247145.
12. [Devi MR, Subramanian NS, Gupta VRM, Prasad BG, Reddy CM. Anti-gastric ulcer activity of Plectranthus amboinicus in Wistar albino rats. J Chem Pharm Res 2010;2:374-80.
13. El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM. Gastroprotective effect of garlic in indomethacin-induced gastric ulcer in rats. Nutrition 2016;32:849-54.
14. Corne SJ. A method for the quantitative estimation of gastric barrier mucus. J Physiol 1974;242:116P-117P.
15. Devasagayam TP, Tarachand U. Decreased lipid peroxidation in the rat kidney during gestation. Biochem Biophys Res Commun 1987;145:134-38.
16. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 1984;21:130-32.
17. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972;47:389-94.
18. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-69.
19. Miwa S. Hematology. Mod Med Technol 1972;3:306-10.
20. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979;582:67-78.
21. Anson ML. The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin. J Gen Physiol 1938;22:79-89.
22. Sipos T, Merkel JR. Effect of calcium ions on the activity, heat stability and structure of trypsin. Biochemistry 1970;9:2766-75.
23. Hummel BC. A modified spectrophotometric determination of chymotrypsin, trypsin and thrombin. Can J Biochem Physiol 1959;37:1393-99.
24. Gamklou R, Schersten T. Activity of alpha-amylase and alpha-1,4-glucosidase in human liver tissue. Scand J Clin Lab Invest 1972;30:201-07.
25. Bergo M, Olivecrona G, Olivecrona T. Forms of lipoprotein lipase in rat tissues. Biochem J 1996;313:893-98.
26. Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 2020;18:e3000410.
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