ARCHIVES

Original Article

Evaluation of Neuroprotective Activity of Delonix Regia Leaves on Haloperidol Induced Parkinsonism in Experimental Animals

Nilesh C. Choudhary1 Dr. S. S. Nipate2 Dr. D. D. Bandawane3
1 2 3 PES’s Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India

Published Online: May-June 2024

Pages: 77-86

References

1. Johnson, M. E., Bobrovskaya, L., 2015. An update on the rotenone models of Parkinson's disease: their ability to reproduce the features
of clinical disease and model gene environment interactions. Neurotoxicology 46, 101-116
2. Erro R, Stamelou M. The motor syndrome of Parkinson's disease. Int Rev Neurobiol. 2017; 132:25–32.
3. Husnul Khotimah, Sutiman B. Sumitro, M. Aris Widodo, Zebrafish Parkinson’s Model: Rotenone decrease motility, Dopamine, and
increase α-synuclein Aggregation and Apoptosis of Zebrafish Brain, International Journal of Pharm Tech Research,2015:614-621
4. Prasad KN, Cole WC, Kumar B. Multiple antioxidants in the prevention and treatment of Parkinson’s disease. J Am Coll Nutr.
1999;18(5):413-23.
5. Perera J, Tan JH, Jeevathayaparan S, Chakravarthi S, Haleagrahara N. Neuroprotective effects of alpha lipoic acid on haloperidol-
induced oxidative stress in the rat brain. Cell Biosci 2011; 1:2e6.
6. Mosley RL, Benner EJ, Kadiu I, Thomas M, Boska MD, Khader Hasan, et al. Neuroinflammation, oxidative stress and the pathogenesis
of Parkinson’s disease. Clin Neurosci Res 2006;6(5):261e81.
7. Shivakumar BR, Ravindranath V. Oxidative stress and thiol modification induced by chronic administration of haloperidol. J Pharmacol
Exp Therapeut 1993; 265:1137e41.
8. Shabir G, Anwar F, Sultana B, Khalid ZM, Afzal M, Khan QM, et al. Antioxidant and antimicrobial attributes and phenolics of different
solvent extracts from leaves, flowers and bark of Gold Mohar [Delonix regia (Bojer ex Hook.) Raf.] Molecules 2011; 1:7302-19.
9. Sama K, Raja AXV, Yadav RH. Antibacterial and pharmacognostical evaluation of Delonix regia root bark. Int J Pharm Life Sci 2012;
3:1628-30.
10. Rani PMJ, Kannan PSM, Kumaravel S. Screening of antioxidant activity, total phenolics and gas chromatograph and mass spectrometer
(GC-MS) study of Delonix regia. Afr J Biochem Res 2011; 5:341-7.
11. Salman A, Toseef S, Mohtasheemul HM, Iqbal A. Antiemetic activity of leaves extracts of five leguminous plants. Int J Res Ayurveda
Pharm 2012; 3:251-3.
12. Deepa B, Remadevi OK. Larvicidal activity of the flowers of Delonix regia (Bojer ex Hook.) Rafin. (Fabales: Fabaceae) against the teak
defoliator, Hyblaea puera. Cramer Curr Biotica 2011; 5:237-40
13. Ahmed J, Nirmal S, Dhasade V, Patil A, Kadam S, Pal A, et al. Hepatoprotective activity of methanol extract of aerial parts of Delonix
regia. Phytopharmacology 2011; 1:118-22.
14. Shiramane RS, Biradar KV, Chivde BV, Shambhulingayya HM, Goud V. In-vivo antidiarrhoel activity of ethanolic extract of Delonix
regia flowers in experimental induced diarrhea in wistar albino rats. Int J Res Pharm Chem 2011; 1:442-7
15. Shewale VD, Deshmukh TA, Patil LS, Patil VR. Anti-inflammatory activity of Delonix regia (Boj. Ex. Hook). Adv Pharmacol Sci doi
2012; 10:1155/2012/789713.
16. Fatmawaty, Fadilah, Astuti H. Antimalarial activity of Delonix regia on mice with Plasmodium berghei. J Nat Prod 2013; 6:61-6
17. Ahirrao RA, Patel MR, Hamid S, Patil JK. In-vitro anthelmintic property of Gulmohar flowers against Pheritima posthuma.
Pharmacologyonline 2011; 1:728-32.
18. Chitra V, Ilango K, Rajanandh MG, Soni D. Evaluation of Delonix regia Linn. Flowers for antiarthritic and antioxidant activity in
female wistar rats. Ann Biol Res 2010; 1:142-7.
19. Khan MA, Saxena A, Fatima FT, Sharma G, Goud V, Husain A. Study of wound healing activity of Delonix regia flowers in experimental
animal models. Am J PharmTech Res 2012; 2:380-90
20. Azab SS, Abdel-Daim M, Eldahshan OA. Phytochemical, cytotoxic, hepatoprotective and antioxidant properties of Delonix regia leaves
extract. Med Chem Res 2013; 22:4269-77
21. Rani JMJ, Chandramohan G, Kumaravel S. Evaluation of antimicrobial activity of some garden plant leaves against Lactobacillus sp,
Streptococcus mitis, Candida albicans and Aspergillus niger. Afr J Basic Appl Sci 2012; 4:139-42.
22. Harborne JB. Phytochemical Methods A guide to modern techniques of plant analysis. 3rd edition. Chapman & Hall; 1998. 40-96 p
23. Kulkarni S K. To study the phenothiazine induced catatonia in rats; Hand book of experimental pharmacology Third edition; 2003: 140.
24. Anil kumar, Kulkarni SK. Effect of BR-16A(Mentat), a poly herbal formulation on drug induced catalepsy in mice. Indian J Exper Biol.
2006; 44:45–48.
25. Samanta M.K et al, Development of Mono Ingredient Herbal neuroleptic tablet for better psychiatric therapy, Indian Journal of
Pharmaceutical Sciences, 2005, 67(1): 51-56.
26. Sakina M.R et al; A Neuropychopharmacological profile of "cinkara", a polyherbal preparation, Ind. Physio. Pharmac., Volume 33,
Number 1,1989.
27. Rabelo, I.D. Oliveira, A.G. Guimaraes, J.S.S Quintans, A.P.N. Prata, D.P. Gelain, Antinociceptive, anti-inflammatory and antioxidant
activities of aqueous extract from Remirea maritima (Cyperaceae), Journal of ethnopharmacology, 145 (2013): 11-17
28. Maham Sanawar, Uzma Saleem, Fareeha Anwar, Samra Nazir, Muhammad Furqan Akhtar, Bashir Ahmad & Tariq Ismail (2020):
Investigation of Anti Parkinson Activity of Dicyclomine, International Journal of Neuroscience, DOI: 10.1080/00207454.2020.1815732
29. H. Aebi, “Catalase in vitro,” in Methods in Enzymology, vol. 105, pp. 121–126, Academic Press, New York, NY, USA, 1984.
30. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical
Biochemistry, vol. 95, no. 2, pp. 351–358, 1979.
31. S. K. Srivastava and E. Beutler, “Accurate measurement of oxidized glutathione content of human, rabbit, and rat red blood cells and
tissues,” Analytical Biochemistry, vol. 25, pp. 70– 76, 1968
32. Charles M, McEwen J, Tabor H et al (eds). Methods of Enzymologists. 1977. Academic press. New York.
33. Rahman H, Eswaraiah M. Simple spectroscopic methods for estimating brain neurotransmitters, antioxidant enzymes of laboratory
animals like mice: A review. Pharmatutor Art. 2008;1244

Related Articles

2024

Matrix Representation of Graph Theory in Hydrocarbons

2024

A Review of Development of Chemical Sensors

2024

Towards Detection and Attribution of Cyber Attacks in IoT Enabled Cyber-Physical Systems

2024

Implementation of Waste Management System

2024

To Study the Role of Forest –Based Industries in Promoting Trade

2024

E-Ticketing for Public buses

Share Article

X
LinkedIn
Facebook
WhatsApp

Or copy link

https://www.ijrtmr.com/archives/10.59256/ijrtmr.20240403013

*Instagram doesn't support direct link sharing from web. Copy the link and share it in your Instagram story or post.