Current - Issue
Year 2026 · Volume 6 · Issue 5
Review Article
Recent Advances, Applications, and Future Perspectives of Sustainable Green Solvents in Pharmaceutical Analysis
Ranjith.T1
Saravanan.V.S2
Jambulingam.M3
1 2 Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode, Tamilnadu, India. 3 Professor, Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode, Tamilnadu, India.
Published Online: September-October 2026
Pages: 204-213
Cite this article
↗ https://www.doi.org/10.59256/ijrtmr.20260605023References
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Chemistry,Volume 18,2019,Pages 42-50,ISSN 2452-2236, https://doi.org/10.1016/j.cogsc.2018.12.010.
2. Cannavacciuolo, C.; Pagliari, S.; Frigerio, J.; Giustra, C.M.; Labra, M.; Campone, L. Natural Deep Eutectic Solvents (NADESs)
Combined with Sustainable Extraction Techniques: A Review of the Green Chemistry Approach in Food Analysis. Foods 2023, 12, 56.
https://doi.org/10.3390/foods12010056
3. Vadgama, H., Desai, S. & Prajapati, P. Green solvents and their role in modern sample preparation for sustainable analytical
chemistry. Discov. Chem. 2, 255 (2025). https://doi.org/10.1007/s44371-025-00325-6
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Pharmaceutical Society, 2026, pp. 1-22. https://doi.org/10.2478/acph-2026-0012.
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https://doi.org/10.1007/s10098-021-02188-8
6. F. G. Calvo-Flores, C. Mingorance-Sánchez, ChemistryOpen 2021, 10, 815. https://doi.org/10.1002/open.202100137
7. Mehta, M., Mehta, D. & Mashru, R. Recent application of green analytical chemistry: eco-friendly approaches for pharmaceutical analysis.
Futur J Pharm Sci 10, 83 (2024). https://doi.org/10.1186/s43094-024-00658-6
8. Shan, Y., Han*, Y., Fan, C., Liu, Y., & Cao, X. (2021). New natural deep eutectic solvents based on aromatic organic acids. Green
Chemistry Letters and Reviews, 14(4), 713–719. https://doi.org/10.1080/17518253.2021.2009579
9. Emma Chevé-Kools, Young Hae Choi, Catherine Roullier, Gwenaël Ruprich-Robert, Raphaël Grougnet, Florence Chapeland-Leclerc,
Frank Hollmann; Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond. Green Chem. 2025;
27 (28): 8360–8385. https://doi.org/10.1039/d4gc06386d
10. Tobiszewski, M. Analytical chemistry with biosolvents. Anal Bioanal Chem 411, 4359–4364 (2019). https://doi.org/10.1007/s00216-019-
01732-2
11. Jia Rhen Loo, Wai Yan Cheah,Chapter 7 - Green solvents for multiphase systems,Editor(s): Kit Chew, Shir Chia, Pau Show,Principles of
Multiple-Liquid Separation Systems,Elsevier,2023,Pages 111-132,ISBN 9780323917285, https://doi.org/10.1016/B978-0-323-91728-
5.00015-9.
12. Kaja Kalinowska, Marta Bystrzanowska, Marek Tobiszewski,Chemometrics approaches to green analytical chemistry procedure
development,Current Opinion in Green and Sustainable Chemistry,Volume 30,2021,100498,ISSN 2452-2236,
https://doi.org/10.1016/j.cogsc.2021.100498.
13. Yabré, M.; Ferey, L.; Somé, I.T.; Gaudin, K. Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for
Pharmaceutical Analysis. Molecules 2018, 23, 1065. https://doi.org/10.3390/molecules23051065
14. Zhang, Y. Smart organic solvent recovery and reuse. Nat Sustain 8, 1419 (2025). https://doi.org/10.1038/s41893-025-01740-4
15. Marek Tobiszewski, Jacek Namieśnik,Greener organic solvents in analytical chemistry,Current Opinion in Green and Sustainable
Chemistry,Volume 5,2017,Pages 1-4,ISSN 2452-2236, https://doi.org/10.1016/j.cogsc.2017.03.002.
16. Di Carlo, A. Environmentally friendly solvents. Nat Energy 10, 287–288 (2025). https://doi.org/10.1038/s41560-025-01740-w
17. Katharina Häckl; Werner Kunz. Some aspects of green solvents. Comptes Rendus. Chimie, Workshop on alternative solvents for synthesis,
extraction, purification, and formulation (WAS 2017) / Workshop international sur les solvants alternatifs pour la synthèse, l'extraction,
la purification et la formulation (WAS 2017) Lyon (France), 27–29 September 2017 / Lyon (France), 27–29 septembre 2017, Volume 21
(2018) no. 6, pp. 572-580.doi: 10.1016/j.crci.2018.03.010
18. Sara E. Herrera-RodrÃ-guez, Neith Pacheco, Teresa Ayora-Talavera, Soledad Pech-Cohuo, Juan C. Cuevas-Bernardino,Chapter 7 -
Advances in the green extraction methods and pharmaceutical applications of bioactive pectins from unconventional sources: a
review,Editor(s): Atta-ur-Rahman,Studies in Natural Products Chemistry,Elsevier,Volume 73,2022,Pages 221-264,ISSN 1572-
5995,ISBN 9780323910972, https://doi.org/10.1016/B978-0-323-91097-2.00015-7.
19. Min Han, Kunze Du, Xicheng He, Haixiang Li, Jin Li, Xiaoxia Li, Yanxu Chang,Advancing green extraction of bioactive compounds
using deep eutectic solvent-based ultrasound-assisted matrix solid-phase dispersion: Application to UHPLC-PAD analysis of alkaloids
and organic acids in Coptidis rhizoma,Talanta,Volume 274,2024,125983,ISSN 0039-9140, https://doi.org/10.1016/j.talanta.2024.125983.
20. A green solvent for the scalable production of cellulose nanofibres. Nat Sustain 7, 236–237 (2024). https://doi.org/10.1038/s41893-024-
01268-z
21. Andrey Shishov, Aleksei Pochivalov, Ivan Dubrovsky, Andrey Bulatov,Deep eutectic solvents with low viscosity for automation of liquid-
phase microextraction based on lab-in-syringe system: Separation of Sudan dyes,Talanta,Volume 255,2023,124243,ISSN 0039-9140,
https://doi.org/10.1016/j.talanta.2022.124243.22. Bianca Aparecida de Marco, Bárbara Saú Rechelo, Eliane Gandolpho Tótoli, Ana Carolina Kogawa, Hérida Regina Nunes
Salgado,Evolution of green chemistry and its multidimensional impacts: A review,Saudi Pharmaceutical Journal,Volume 27, Issue
1,2019,Pages 1-8,ISSN 1319-0164, https://doi.org/10.1016/j.jsps.2018.07.011.
23. Mohamed HM (2022) SolventlessMicroextration Techniques forPharmaceutical Analysis: TheGreener Solution.Front. Chem.
9:785830.doi: 10.3389/fchem.2021.785830
24. Feng Gao, Rongxian Bai, Francesco Ferlin, Luigi Vaccaro, Minghao Li, Yanlong Gu; Replacement strategies for non-green dipolar aprotic
solvents. Green Chem. 2020; 22 (19): 6240–6257. https://doi.org/10.1039/d0gc02149k
25. Adrián Gutiérrez-Serpa, Diego W. Allgaier-Díaz, Ana I. Jiménez-Abizanda, Verónica Pino,Chapter 2 - Green sorbents in analytical
chemistry,Editor(s): Emanuela Gionfriddo,Green Approaches for Chemical Analysis,Elsevier,2023,Pages 39-83,ISBN 9780128222348,
https://doi.org/10.1016/B978-0-12-822234-8.00003-2.
26. Chun-Chi Chen, Yen-Hui Huang, Jia-Yu Fang,Hydrophobic deep eutectic solvents as green absorbents for hydrophilic VOC
elimination,Journal of Hazardous Materials,Volume 424, Part B,2022,127366,ISSN 0304-3894,
https://doi.org/10.1016/j.jhazmat.2021.127366.
27. Lawrenson, Stefan B.. "Greener solvents for solid-phase organic synthesis" Pure and Applied Chemistry, vol. 90, no. 1, 2018, pp. 157-
165. https://doi.org/10.1515/pac-2017-0505
28. Oktawia Kalisz, Gabriela Hulicka, Marek Tobiszewski, Szymon Bocian; Performance evaluation of green and conventional solvents in
reversed-phase liquid chromatography based on the separation of non-polar and polar substances. Green Chem. 2025; 27 (11): 3020–
3031. https://doi.org/10.1039/d4gc05737f
29. Passerini, Bianca & Breitkreitz, Márcia. (2023). Recent Developments in Green Chromatography. Brazilian Journal of Analytical
Chemistry. 10.30744/brjac.2179-3425.RV-126-2022.
30. Tobiszewski, M. Analytical chemistry with biosolvents. Anal Bioanal Chem 411, 4359–4364 (2019). https://doi.org/10.1007/s00216-019-
01732-2
Chemistry,Volume 18,2019,Pages 42-50,ISSN 2452-2236, https://doi.org/10.1016/j.cogsc.2018.12.010.
2. Cannavacciuolo, C.; Pagliari, S.; Frigerio, J.; Giustra, C.M.; Labra, M.; Campone, L. Natural Deep Eutectic Solvents (NADESs)
Combined with Sustainable Extraction Techniques: A Review of the Green Chemistry Approach in Food Analysis. Foods 2023, 12, 56.
https://doi.org/10.3390/foods12010056
3. Vadgama, H., Desai, S. & Prajapati, P. Green solvents and their role in modern sample preparation for sustainable analytical
chemistry. Discov. Chem. 2, 255 (2025). https://doi.org/10.1007/s44371-025-00325-6
4. Zechen, Li. "Deep eutectic solvents in pharmaceutical applications: A review." Acta Pharmaceutica, vol. 76, no. 2, Croatian
Pharmaceutical Society, 2026, pp. 1-22. https://doi.org/10.2478/acph-2026-0012.
5. Winterton, N. The green solvent: a critical perspective. Clean Techn Environ Policy 23, 2499–2522 (2021).
https://doi.org/10.1007/s10098-021-02188-8
6. F. G. Calvo-Flores, C. Mingorance-Sánchez, ChemistryOpen 2021, 10, 815. https://doi.org/10.1002/open.202100137
7. Mehta, M., Mehta, D. & Mashru, R. Recent application of green analytical chemistry: eco-friendly approaches for pharmaceutical analysis.
Futur J Pharm Sci 10, 83 (2024). https://doi.org/10.1186/s43094-024-00658-6
8. Shan, Y., Han*, Y., Fan, C., Liu, Y., & Cao, X. (2021). New natural deep eutectic solvents based on aromatic organic acids. Green
Chemistry Letters and Reviews, 14(4), 713–719. https://doi.org/10.1080/17518253.2021.2009579
9. Emma Chevé-Kools, Young Hae Choi, Catherine Roullier, Gwenaël Ruprich-Robert, Raphaël Grougnet, Florence Chapeland-Leclerc,
Frank Hollmann; Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond. Green Chem. 2025;
27 (28): 8360–8385. https://doi.org/10.1039/d4gc06386d
10. Tobiszewski, M. Analytical chemistry with biosolvents. Anal Bioanal Chem 411, 4359–4364 (2019). https://doi.org/10.1007/s00216-019-
01732-2
11. Jia Rhen Loo, Wai Yan Cheah,Chapter 7 - Green solvents for multiphase systems,Editor(s): Kit Chew, Shir Chia, Pau Show,Principles of
Multiple-Liquid Separation Systems,Elsevier,2023,Pages 111-132,ISBN 9780323917285, https://doi.org/10.1016/B978-0-323-91728-
5.00015-9.
12. Kaja Kalinowska, Marta Bystrzanowska, Marek Tobiszewski,Chemometrics approaches to green analytical chemistry procedure
development,Current Opinion in Green and Sustainable Chemistry,Volume 30,2021,100498,ISSN 2452-2236,
https://doi.org/10.1016/j.cogsc.2021.100498.
13. Yabré, M.; Ferey, L.; Somé, I.T.; Gaudin, K. Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for
Pharmaceutical Analysis. Molecules 2018, 23, 1065. https://doi.org/10.3390/molecules23051065
14. Zhang, Y. Smart organic solvent recovery and reuse. Nat Sustain 8, 1419 (2025). https://doi.org/10.1038/s41893-025-01740-4
15. Marek Tobiszewski, Jacek Namieśnik,Greener organic solvents in analytical chemistry,Current Opinion in Green and Sustainable
Chemistry,Volume 5,2017,Pages 1-4,ISSN 2452-2236, https://doi.org/10.1016/j.cogsc.2017.03.002.
16. Di Carlo, A. Environmentally friendly solvents. Nat Energy 10, 287–288 (2025). https://doi.org/10.1038/s41560-025-01740-w
17. Katharina Häckl; Werner Kunz. Some aspects of green solvents. Comptes Rendus. Chimie, Workshop on alternative solvents for synthesis,
extraction, purification, and formulation (WAS 2017) / Workshop international sur les solvants alternatifs pour la synthèse, l'extraction,
la purification et la formulation (WAS 2017) Lyon (France), 27–29 September 2017 / Lyon (France), 27–29 septembre 2017, Volume 21
(2018) no. 6, pp. 572-580.doi: 10.1016/j.crci.2018.03.010
18. Sara E. Herrera-RodrÃ-guez, Neith Pacheco, Teresa Ayora-Talavera, Soledad Pech-Cohuo, Juan C. Cuevas-Bernardino,Chapter 7 -
Advances in the green extraction methods and pharmaceutical applications of bioactive pectins from unconventional sources: a
review,Editor(s): Atta-ur-Rahman,Studies in Natural Products Chemistry,Elsevier,Volume 73,2022,Pages 221-264,ISSN 1572-
5995,ISBN 9780323910972, https://doi.org/10.1016/B978-0-323-91097-2.00015-7.
19. Min Han, Kunze Du, Xicheng He, Haixiang Li, Jin Li, Xiaoxia Li, Yanxu Chang,Advancing green extraction of bioactive compounds
using deep eutectic solvent-based ultrasound-assisted matrix solid-phase dispersion: Application to UHPLC-PAD analysis of alkaloids
and organic acids in Coptidis rhizoma,Talanta,Volume 274,2024,125983,ISSN 0039-9140, https://doi.org/10.1016/j.talanta.2024.125983.
20. A green solvent for the scalable production of cellulose nanofibres. Nat Sustain 7, 236–237 (2024). https://doi.org/10.1038/s41893-024-
01268-z
21. Andrey Shishov, Aleksei Pochivalov, Ivan Dubrovsky, Andrey Bulatov,Deep eutectic solvents with low viscosity for automation of liquid-
phase microextraction based on lab-in-syringe system: Separation of Sudan dyes,Talanta,Volume 255,2023,124243,ISSN 0039-9140,
https://doi.org/10.1016/j.talanta.2022.124243.22. Bianca Aparecida de Marco, Bárbara Saú Rechelo, Eliane Gandolpho Tótoli, Ana Carolina Kogawa, Hérida Regina Nunes
Salgado,Evolution of green chemistry and its multidimensional impacts: A review,Saudi Pharmaceutical Journal,Volume 27, Issue
1,2019,Pages 1-8,ISSN 1319-0164, https://doi.org/10.1016/j.jsps.2018.07.011.
23. Mohamed HM (2022) SolventlessMicroextration Techniques forPharmaceutical Analysis: TheGreener Solution.Front. Chem.
9:785830.doi: 10.3389/fchem.2021.785830
24. Feng Gao, Rongxian Bai, Francesco Ferlin, Luigi Vaccaro, Minghao Li, Yanlong Gu; Replacement strategies for non-green dipolar aprotic
solvents. Green Chem. 2020; 22 (19): 6240–6257. https://doi.org/10.1039/d0gc02149k
25. Adrián Gutiérrez-Serpa, Diego W. Allgaier-Díaz, Ana I. Jiménez-Abizanda, Verónica Pino,Chapter 2 - Green sorbents in analytical
chemistry,Editor(s): Emanuela Gionfriddo,Green Approaches for Chemical Analysis,Elsevier,2023,Pages 39-83,ISBN 9780128222348,
https://doi.org/10.1016/B978-0-12-822234-8.00003-2.
26. Chun-Chi Chen, Yen-Hui Huang, Jia-Yu Fang,Hydrophobic deep eutectic solvents as green absorbents for hydrophilic VOC
elimination,Journal of Hazardous Materials,Volume 424, Part B,2022,127366,ISSN 0304-3894,
https://doi.org/10.1016/j.jhazmat.2021.127366.
27. Lawrenson, Stefan B.. "Greener solvents for solid-phase organic synthesis" Pure and Applied Chemistry, vol. 90, no. 1, 2018, pp. 157-
165. https://doi.org/10.1515/pac-2017-0505
28. Oktawia Kalisz, Gabriela Hulicka, Marek Tobiszewski, Szymon Bocian; Performance evaluation of green and conventional solvents in
reversed-phase liquid chromatography based on the separation of non-polar and polar substances. Green Chem. 2025; 27 (11): 3020–
3031. https://doi.org/10.1039/d4gc05737f
29. Passerini, Bianca & Breitkreitz, Márcia. (2023). Recent Developments in Green Chromatography. Brazilian Journal of Analytical
Chemistry. 10.30744/brjac.2179-3425.RV-126-2022.
30. Tobiszewski, M. Analytical chemistry with biosolvents. Anal Bioanal Chem 411, 4359–4364 (2019). https://doi.org/10.1007/s00216-019-
01732-2
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