Current - Issue
Year 2026 · Volume 6 · Issue 5
Original Article
In Vitro Anti-Diabetic Activity of Terminalia arjuna Bark by DPP-4 Inhibition Assay
S. Elayaraja1
Dr. A.M. Ramanandha Mishra2
Dr .S .Mohammad Halith3
S. Ramanan4
R. Ramya5
S. Ravichandran6
A. Rufina Shilphia7
M. Sakthivel8
1 3 4 5 6 7 8 Department of Pharmacy Practice, Dhanalakshmi Srinivasan College of Pharmacy, Perambalur, Tamil Nadu, India. 2 Pharm.D, Assistant Professor, Department of Pharmacy Practice, Dhanalakshmi Srinivasan College of Pharmacy, Perambalur, Tamil Nadu, India.
Published Online: September-October 2026
Pages: 237-248
Cite this article
No DOIReferences
1. Adlak P, Sagar R, Kori ML. Potent antidiabetic activity of ethanolic extract of Terminalia arjuna fruits on streptozotocin-induced diabetic Wistar albino rats. Int J Life Sci Pharma Res. 2023;13(1):P87-P97.
2. Akhare YD, Sharma S. Effect of Terminalia arjuna bark extract on streptozotocin-induced diabetic rats. Int J Curr Sci Res Rev. 2022;5(4):1044-1048. doi:10.47191/ijcsrr/V5-i4-24.
3. Abinaya M, Kalki R, Sibichanduru E, Sivalbanan A, Saravanan S, Vadivel SA. A comprehensive review of phytomolecules used in anti-diabetic activities. Eur J Biomed Pharm Sci. 2024;11(6):77-90.
4. Verma A, et al. Bioactive compounds and regulation of blood glucose levels via α-amylase and α-glucosidase inhibition. 2017.
5. Gupta S, et al. Enhancement of insulin sensitivity by plant bioactive compounds. 2019.
6. Murthy K, et al. Extracts of Justicia tranquebarensis improve glucose uptake in vitro. 2020.
7. Rajesh R, et al. Protective effects of plant extracts against oxidative stress in diabetes. 2021.
8. Singh P, et al. Plant extracts and fasting blood glucose reduction in diabetic patients. 2022.
9. Deshmukh S, et al. Reduction of inflammation and oxidative damage by plant extracts. 2018.
10. Iyer R, et al. Anti-inflammatory and antioxidant potential of medicinal plant extracts in diabetes. 2021.
11. Rao V, Singh N. Ethnobotanical use of medicinal plants for blood sugar regulation and wound healing. 2017-2018.
12. Nair A, et al. Inhibition of α-amylase and α-glucosidase enzymes by plant extracts. 2023.
13. Wallis TE. Analytical Microscopy – Its Aims and Methods in Relation to Foods, Water, Spices and Drugs. 3rd ed. Boston: Little, Brown and Company; 1965.
14. Khandelwal KR. Practical Pharmacognosy. 19th ed. Pune: Nirali Prakashan; 2008.
15. Fahn A. Plant Anatomy. 3rd ed. Oxford: Pergamon Press; 1980.
16. Gopi DK, Remya A, Brindha S, Sunil Kumar KN, Sathiya Rajeshwaran P. Comparative macro-microscopic atlas of two aroids used in Siddha medicine. Ayu Med Sci. 2017;2(4):256-260.
17. Kokate CK. Practical Pharmacognosy. 4th ed. Pune: Rajkamal Electric Press; 2005. p.545-547.
18. Dr. Duke's Phytochemical and Ethnobotanical Databases [Internet]. USDA-ARS-NGRL; [cited 2021 Jan 5]. Available from: https://phytochem.nal.usda.gov/phytochem/plants/show/1366.
19. World Health Organization. Quality Control Methods for Medicinal Plant Materials. Geneva: WHO; 1998. p.128.
20. Ayurvedic Pharmacopoeia of India. New Delhi: The Controller of Publications; 2001. p.143.
21. Indian Pharmacopoeia. New Delhi: The Controller of Publications; 1996. p.47-60.
22. Beckett AH, Stenlake JB. Practical Pharmaceutical Chemistry. 2nd ed. New Delhi: CBS Publishers; 2001. p.115-126.
23. Kumar A, Chakraborty D, Pathak D, Shukla AK. Comparative pharmacognostic evaluation of Terminalia arjuna (Roxb. ex DC.) Wight and Arn. and Terminalia elliptica Willd. Pharmacogn Res. 2026;18(2):599-608. doi:10.5530/pres.20260161.
2. Akhare YD, Sharma S. Effect of Terminalia arjuna bark extract on streptozotocin-induced diabetic rats. Int J Curr Sci Res Rev. 2022;5(4):1044-1048. doi:10.47191/ijcsrr/V5-i4-24.
3. Abinaya M, Kalki R, Sibichanduru E, Sivalbanan A, Saravanan S, Vadivel SA. A comprehensive review of phytomolecules used in anti-diabetic activities. Eur J Biomed Pharm Sci. 2024;11(6):77-90.
4. Verma A, et al. Bioactive compounds and regulation of blood glucose levels via α-amylase and α-glucosidase inhibition. 2017.
5. Gupta S, et al. Enhancement of insulin sensitivity by plant bioactive compounds. 2019.
6. Murthy K, et al. Extracts of Justicia tranquebarensis improve glucose uptake in vitro. 2020.
7. Rajesh R, et al. Protective effects of plant extracts against oxidative stress in diabetes. 2021.
8. Singh P, et al. Plant extracts and fasting blood glucose reduction in diabetic patients. 2022.
9. Deshmukh S, et al. Reduction of inflammation and oxidative damage by plant extracts. 2018.
10. Iyer R, et al. Anti-inflammatory and antioxidant potential of medicinal plant extracts in diabetes. 2021.
11. Rao V, Singh N. Ethnobotanical use of medicinal plants for blood sugar regulation and wound healing. 2017-2018.
12. Nair A, et al. Inhibition of α-amylase and α-glucosidase enzymes by plant extracts. 2023.
13. Wallis TE. Analytical Microscopy – Its Aims and Methods in Relation to Foods, Water, Spices and Drugs. 3rd ed. Boston: Little, Brown and Company; 1965.
14. Khandelwal KR. Practical Pharmacognosy. 19th ed. Pune: Nirali Prakashan; 2008.
15. Fahn A. Plant Anatomy. 3rd ed. Oxford: Pergamon Press; 1980.
16. Gopi DK, Remya A, Brindha S, Sunil Kumar KN, Sathiya Rajeshwaran P. Comparative macro-microscopic atlas of two aroids used in Siddha medicine. Ayu Med Sci. 2017;2(4):256-260.
17. Kokate CK. Practical Pharmacognosy. 4th ed. Pune: Rajkamal Electric Press; 2005. p.545-547.
18. Dr. Duke's Phytochemical and Ethnobotanical Databases [Internet]. USDA-ARS-NGRL; [cited 2021 Jan 5]. Available from: https://phytochem.nal.usda.gov/phytochem/plants/show/1366.
19. World Health Organization. Quality Control Methods for Medicinal Plant Materials. Geneva: WHO; 1998. p.128.
20. Ayurvedic Pharmacopoeia of India. New Delhi: The Controller of Publications; 2001. p.143.
21. Indian Pharmacopoeia. New Delhi: The Controller of Publications; 1996. p.47-60.
22. Beckett AH, Stenlake JB. Practical Pharmaceutical Chemistry. 2nd ed. New Delhi: CBS Publishers; 2001. p.115-126.
23. Kumar A, Chakraborty D, Pathak D, Shukla AK. Comparative pharmacognostic evaluation of Terminalia arjuna (Roxb. ex DC.) Wight and Arn. and Terminalia elliptica Willd. Pharmacogn Res. 2026;18(2):599-608. doi:10.5530/pres.20260161.
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