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Review Article

Endophytic Microorganisms as a Source of Novel Bioactive Compounds for Drug Discovery and Development

Aayush Kurmi1 Khushboo Kurmi2 Sanjana Rajput3 Niharika Singh4 Sarvar Jahan5
1 2 3 4 Students of B.sc Forensic science (6th semester), School of science, SAM Global University, Bhopal, Madhya Pradesh, India. 5 Assistant Professor, School of Science, SAM Global University, Raisen, Bhopal, Madhya Pradesh, India.

Published Online: May-June 2026

Pages: 162-165

References

1. Beutler J. A. (2019). Natural products as a foundation for drug discovery.
2. Curr. Protoc. Pharmacol.86(1), e67.10.1002/cpph.67
3. Li, z. Chen, k., Rose, P., & Zhu, Y.Z. (2022). Natural products in drug discovery and development: Synthesis and medicinal perspective
of leonurine. Frontiers in Chemistry, drug. Journal of Natural Products.
4. Fabricant, D. S., & Fransworth, N.R. (2001). The value of plants used in traditional medicine. Environmental Health Perspectives.
5. Butler, M. S. (2004). The role of natural product chemistry in drug discovery. Journal of Natural Products.
6. Dewick, P. M. (2009). Medicinal Natural Prodoucts: A biosynthetic Approach. Wiley.
7. Rates, S. M. K. (20010. Plants as source of drugs. Toxicon. Kiriiri, G. K., Njogu, P. M., & Mwangi, A. N. (2020).Exploring different
approaches to improve the success of drug discovery and development projects: a review.
8. Potterat O, Hamburger M. Drug discovery and development with plant-derived compounds. Natural Compounds as Drugs Volume I.
2008 Jan 1:45-118.
9. Berdigaliyev N, Aljofan M. An overview of drug discovery and development. Future medicinal chemistry. 2020 May 1;12(10):939-47.
10. Nicolaou KC. Advancing the drug discovery and development process. Angewandte Chemie. 2014 Aug 25;126(35):9280-92
11. Sinha S, Vohora D. Drug discovery and development: An overview. Pharmaceutical medicine and translational clinical research. 2018
Jan 1:19-32.
12. Subbaiah, M.A., Rautio, J. and Meanwell, N.A., 2024. Prodrugs as empowering tools in drug discovery and development: recent
strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates. Chemical
Society Reviews, 53(4), pp.2099-2210.
13. Sarvepalli S, Vadarevu S. Role of artificial intelligence in cancer drug discovery and development. Cancer letters. 2025 Sep 1;
627:217821.
14. Blass BE. Basic principles of drug discovery and development. Elsevier; 2015 Apr 24.
15. SAMQUEST-Journal of Emerging, Sarvar Jahan Innovations,Qualitative and Quantitative Analysis of Photochemical and Study of the
Effect of Phytoconstituents in Seed Germination, Vol.1, Issue1,pp. 48-52 ,Jan-June2025.
16. SAMQUEST-Journal of Emerging Innovations,Neelanjana Namdev,Forensic Screening of Medicinal Plants for Qualitative
Photochemical Analysis Using Various Solvent Extracts, Vol.1, Issue 1, pp.37-41 , Jan-June 202517. SAMQUEST-Journal of Emerging Innovations,VarunJain1*,Sohan Kumar2 , Ruchi Upadhyay1, Isolation and Characterization of
Volatile Contents from Ocimum basilicum,Vol.1, Issue 1, pp.34-36 ,June2025.
18. Sinha S, Vohora D. Drug discovery and development: An overview. Pharmaceutical medicine and translational clinical research. 2018
Jan 1:19-32.
19. Subbaiah, M.A., Rautio, J. and Meanwell, N.A., 2024. Prodrugs as empowering tools in drug discovery and development: recent
strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates. Chemical
Society Reviews, 53(4), pp.2099-2210.
20. Sarvepalli S, Vadarevu S. Role of artificial intelligence in cancer drug discovery and development. Cancer letters. 2025 Sep
1;627:217821.
21. Chatelain E, Ioset JR. Drug discovery and development for neglected diseases: the DND i model. Drug design, development and therapy.
2011 Mar 16:175-81.
22. Deore AB, Dhumane JR, Wagh R, Sonawane R. The stages of drug discovery and development process. Asian Journal of Pharmaceutical
Research and Development. 2019 Dec 15;7(6):62-7.
23. Singh K, Gupta JK, Chanchal DK, Shinde MG, Kumar S, Jain D, Almarhoon ZM, Alshahrani AM, Calina D, Sharifi-Rad J, Tripathi A.
Natural products as drug leads: exploring their potential in drug discovery and development. Naunyn-Schmiedeberg's Archives of
Pharmacology. 2025 May;398(5):4673-87.
24. Gajula SN, Nadimpalli N, Sonti R. Drug metabolic stability in early drug discovery to develop potential lead compounds. Drug
metabolism reviews. 2021 Jul 3;53(3):459-77.
25. Mans DR, Rocha AB, Schwartsmann G. Anti-cancer drug discovery and development in Brazil: targeted plant collection as a rational
strategy to acquire candidate anti-cancer compounds. The oncologist. 2000 Jun 1;5(3):185-98.
26. LaPlante SR, Fader LD, Fandrick KR, Fandrick DR, Hucke O, Kemper R, Miller SP, Edwards PJ. Assessing atropisomer axial chirality
in drug discovery and development. Journal of medicinal chemistry. 2011 Oct 27;54(20):7005-22.
27. Harbeson SL, Tung RD. Deuterium in drug discovery and development. InAnnual reports in medicinal chemistry 2011 Jan 1 (Vol. 46,
pp. 403-417). Academic Press.

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