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Original Article
Diffusion-FLAIR Mismatch as a Selection Criteria for Patient Eligibility for Mechanical Thrombectomy
Hossam Mohsen Hassan Husssein Ali1
Amr Mahmoud Abdel-Samad2
1 2 Department of Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Published Online: May-June 2026
Pages: 66-72
Cite this article
↗ https://www.doi.org/10.59256/ijrtmr.20260603008
References
1. Fink JN, Kumar S, Horkan C, Linfante I, Selim MG, Caplan LR, et al.: The stroke patient who woke up: clinical and radiological
features, including diffusion and perfusion MRI. Stroke 2002; 33:988 –93. doi: 10.1161/01.str.0000014585.17714.67.
2. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. : Thrombolysis with alteplase 3 to 4.5 hours after acute
ischemic stroke. N Engl J Med 2008; 359:1317–29. doi: 10.1056/NEJMoa0804656.
3. Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, et al, DWI-FLAIR mismatch for the identification of patients with
acute ischaemic stroke within 4.5 h of symptom onset (PRE-FLAIR): a multicentrer observational study. Lancet Neurol 2011; 10:978 –
86. doi: 10.1016/S1474-4422(11)70192-2.
4. Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, et al.: Thrombectomy 6 to 24 Hours after Stroke with a
Mismatch between Deficit and Infarct. N. Engl. J. Med. 2018; 378, 11–21. doi: 10.1056/NEJMoa1706442
5. Hernández-Pérez M, Pérez de la Ossa N, Aleu A, Milan M, Gomis M, Dorada L, et al.: Natural history of acute stroke due to occlusion
of the middle cerebral artery and intracranial internal carotid artery. J Neuroimaging 2014; 24:354-358. doi: 10.1111/jon.12062.
6. Albers GW, Lansberg MG, Kemp S, Tsai JP, Lavori P, and Christensen S, et al.: A multicenter randomized controlled trial of
endovascular therapy following imaging evaluation for ischemic stroke (DEFUSE 3). Int J Stroke 2017; 12:896-905. doi:
10.1177/1747493017701147.
features, including diffusion and perfusion MRI. Stroke 2002; 33:988 –93. doi: 10.1161/01.str.0000014585.17714.67.
2. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. : Thrombolysis with alteplase 3 to 4.5 hours after acute
ischemic stroke. N Engl J Med 2008; 359:1317–29. doi: 10.1056/NEJMoa0804656.
3. Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, et al, DWI-FLAIR mismatch for the identification of patients with
acute ischaemic stroke within 4.5 h of symptom onset (PRE-FLAIR): a multicentrer observational study. Lancet Neurol 2011; 10:978 –
86. doi: 10.1016/S1474-4422(11)70192-2.
4. Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, et al.: Thrombectomy 6 to 24 Hours after Stroke with a
Mismatch between Deficit and Infarct. N. Engl. J. Med. 2018; 378, 11–21. doi: 10.1056/NEJMoa1706442
5. Hernández-Pérez M, Pérez de la Ossa N, Aleu A, Milan M, Gomis M, Dorada L, et al.: Natural history of acute stroke due to occlusion
of the middle cerebral artery and intracranial internal carotid artery. J Neuroimaging 2014; 24:354-358. doi: 10.1111/jon.12062.
6. Albers GW, Lansberg MG, Kemp S, Tsai JP, Lavori P, and Christensen S, et al.: A multicenter randomized controlled trial of
endovascular therapy following imaging evaluation for ischemic stroke (DEFUSE 3). Int J Stroke 2017; 12:896-905. doi:
10.1177/1747493017701147.
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